General
Preferred name
daporinad
Synonyms
FK866 ()
APO866 ()
(E)-Daporinad ()
(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE ()
APO866(E)-Daporinad ()
Daporinad(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE ()
FK 866 ()
FK 866 hydrochloride ()
FK-866 ()
2016-06-07: APO-866 ()
FK866, APO866 ()
APO-866 ()
APO 866 ()
K 22.175 ()
P&D ID
PD003411
CAS
658084-64-1
1785666-54-7
Tags
available
probe
drug candidate
Drug indication
leukaemia
Drug Status
investigational
Max Phase
2.0
Probe info
Probe selectivity
protein-selective
Probe type
P&D approved
experimental probe
calculated probe
Probe sources
Chemical Probes.org
High-quality chemical probes
Probe Miner (suitable probes)
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION FK866 is a highly specific non-competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT; P43490) , an enzyme required for the biosynthesis of nicotinamide adenine dinucleotide (NAD+).
DESCRIPTION FK866 is a highly specific non-competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT; P43490) , an enzyme required for the biosynthesis of nicotinamide adenine dinucleotide (NAD+). (GtoPdb)
MOA Inhibitor (Chemical Probes.org)
DESCRIPTION inhibitor of nicotinamide phosphoribosyltransferase (Informer Set)
DESCRIPTION FK 866 hydrochloride is a non-competitive and potent inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, visfatin, PBEF1) (Ki = 0.3 nM) and inhibits NAD biosynthesis. It induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 ~1 nM)and induces apoptosis in four different neuroblastoma cell lines. FK 866 exhibits antineoplastic and antiangiogenic activities. (BOC Sciences Bioactive Compounds)
Cell lines
27
Organisms
0
Compound Sets
22
AdooQ Bioactive Compound Library
A11279
Axon Medchem Screening Library
1279
1546
BOC Sciences Bioactive Compounds
fk-866-hydrochloride-item-119132
Cayman Chemical Bioactives
13287
ChEMBL Drugs
CHEMBL566757
Chemical Probes.org
daporinad
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB12731
DrugMAP
DMCU74R
Guide to Pharmacology
7745
High-quality chemical probes
PD003411
Informer Set
418166
JUMP-Target 1 Compound Set
6914657
MedChem Express Bioactive Compound Library
HY-50876
Novartis Chemogenetic Library (NIBR MoA Box)
Other bioactive compounds
Probe Miner (suitable probes)
P43490/174287
ReFrame library
Selleckchem Bioactive Compound Library
apo866-fk866
TargetMol Bioactive Compound Library
T2644
Welcome Trust Cancer Drugs
1248
External IDs
38
Properties
(calculated by RDKit )
Molecular Weight
391.23
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
2
cLogP
3.93
TPSA
62.3
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
NAMPT
NAMPT inhibitor
NMPRTase
Autophagy,NAMPT,Transferase
Compound status
clinical
Pathway
Metabolism
Autophagy
Metabolic Enzyme/Protease
MOA
Transferase inhibitor
Angiogenesis Inhibitors
Apoptosis Inducers
Nicotinamide Phosphoribosyltransferase (NMPRTase) Inhibitors
niacinamide phosphoribosyltransferase inhibitor
Member status
member
Target class
Enzyme
Target subclass
Nicotinamide phosphoribosyltransferase
Source data